Naveen Jain on the Human Ecosystem and Personalized Optimization of Your Gut Health

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Katie: Hiya and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here in the present day with my buddy, Naveen, who’s an intensely curious entrepreneur who has been taking over some large, audacious concepts to push humanity ahead. He’s the creator of the award-winning guide “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Categorical, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Sensible, amongst others.

And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness optionally available by predicting and stopping persistent illness by way of a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse persistent illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Artistic Individual by Quick Firm, High 20 Entrepreneurs, and lots of extra.

On this episode, we discuss concerning the human ecosystem and personalised optimization of your intestine well being and your total well being. We discuss concerning the cause the intestine impacts the whole physique. Why it’s not simply genetics from our mother and father however truly our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at start and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.

The distinction between DNA and gene expression. How some meals may be good for some individuals and never others, and methods to know which is finest for you, but in addition, the universally dangerous meals. Why there are some universality dangerous ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The true cause it’s essential to chew your meals rather well earlier than swallowing, and a lot extra. Lot’s of sensible data on this episode. Additionally, plenty of hyperlinks to study extra within the present notes at wellnessmama.fm, so examine these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.

Naveen: Nicely, Katie, so good to see you lastly after a protracted, very long time.

Katie: I’m so excited we get to have a dialog and get to document it and share it in the present day, and we’re gonna discuss loads about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply discuss this as a result of I believe you’re my solely hobbyist Moon rock collector.

Naveen: Nicely, I believe, Katie, you already know, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a method of expressing that there’s nothing that’s not possible for us to do. Despite the fact that it’s known as “Moonshots” that folks thought was troublesome, if not not possible to do and having, you already know, now to have the ability to go to the Moon and to me, the gathering of area rocks truly was simply merely a pastime of capable of maintain one thing in your hand. Which may be even earlier than the start of our planet. And it offers you some thought of how fragile we’re that if we don’t maintain ourselves, our planet, we as humanity might not survive. As a species, we might not survive.

So, you already know, thought of when somebody says, “I’m actually fearful about our planet,” ask the planet and planet will inform you, “Don’t you are worried about me as a result of we…” Planet will do exactly tremendous however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing outdoors us goes fallacious, we as inside ecosystem can even be impacted, proper. And that’s coming right down to, you already know, should you take a look at what’s above, so under is basically what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.

Katie: I really like that you just mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you already know him as properly. And I requested him that query. , your technology’s gonna face loads within the environmental and local weather stuff. And, I raised this query and he goes, “Nicely, mother, you’re truly asking the fallacious query as a result of the…”

Naveen: Oh, I find it irresistible, I find it irresistible.

Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we should be asking how we may be extra synergistic inside an atmosphere that’s larger than us.”

Naveen: That’s the good reply. That’s precisely how I might see it that…you already know, when individuals say, “Aren’t you fearful concerning the planet?” I say, “That’s not the query you ought to be asking.” It’s, “Are we fearful concerning the human species?” That’s what we needs to be asking.

Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not fearful about however working to resolve. My listeners are fairly well being savvy and perceive or no less than have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…properly, we’ve identified facets of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of corporations like Viome, we’ve many extra tangible instruments to truly perceive and begin to do one thing about that. However to begin broad, sort of give us an outline of what we imply by the well being of the intestine impacts the well being of the entire physique.

Naveen: So, properly, initially, you already know, let’s simply begin from the start. We as human beings should not merely a product of the DNA from our mother and pop. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be truly expressed in our human physique should not our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such when it comes to all of the genes which can be expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re residing of their world. They don’t dwell in our world, proper.

So, after we perceive that, you already know, though you possibly can argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you possibly can argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and comfy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t understand, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.

Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by way of the start canal, that is the primary publicity the infant will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by way of start canal. And sadly, a number of the moms for apparent causes find yourself getting a C-section. They really…the infants should not going by way of the identical…they’re uncovered to pores and skin microbiome relatively by way of the start canal, the microbiome that they’d get by way of the start canal. And that may be a essentially…the infant, when it’s born, is definitely…the character has created in a method that the microbes get launched into the infant on the time of the start and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.

And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the basic half that folks want to grasp. Seventy p.c of our immune system is alongside our intestine lining. Actually, all of the analysis reveals that how intestine microbiome is consistently coaching our immune system what’s a buddy and what’s a foe, proper. So, in some sense, should you take a look at the human physique, there’s a tube that goes by way of us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definitely begin to have a look at all alongside the traces there’s a huge quantity of microbial existence there. And so they the truth is are always interacting with our immune system and the immune system is now understanding when there may be truly a pathogen that’s coming by way of the meals or the pathogen that’s coming by way of the skin world, methods to react to it. And these microbes are the primary sign that tells the immune techniques, “This isn’t good. Go do one thing about it, proper.”

And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we reduce our pores and skin or whether or not there may be some sort of pathogen or we get some sort of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are always in sync and wholesome and our immune system is wholesome, then our physique will truly heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique is just not comfortable, you get illness which we name illness.

Katie: Yeah, so many essential factors you simply mentioned to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you mentioned you’re what you eat however it goes up to now past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you just introduced up the start canal factor as a result of I’m a doula and I’ve truly helped in a number of C-section births with feeding the infant, as a result of such as you mentioned, should you don’t…the infant is of course meant to seed their intestine by way of the start canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which can be in that room, every kind of issues. And we all know that this intestine micro organism at start, increasingly more we study, units you up to your complete life. But additionally, the excellent news is…and I do know that Viome does lots of analysis on this. All is just not misplaced should you don’t get an ideal begin. We now have the flexibility to sort of get a snapshot and look within the intestine in a extremely distinctive method after which optimize to enhance somebody’s well being going ahead.

And likewise, such as you mentioned, the physique’s pure state is well being. It’s not usually that we have to do something drastic. We have to get out of our personal method and simply take away the issues which can be holding the physique from being wholesome or perhaps typically give it little additional vitamins to assist get there. Speak somewhat bit concerning the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair many years in the past, and now we’ve such superb knowledge from this.

Naveen: Nicely, it’s very fascinating is this concept of, you already know…should you return and take a look at couple of many years in the past, it was truly the micro organism and all these organisms have been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as doable as a result of they will’t presumably be there for our good, proper. And as we began to study extra concerning the human physique, we realized that the majority of those organisms are literally commensal. They’re speculated to be there they usually the truth is…after we feed them issues like, you already know…in olden days, after we have been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, truly flip them into quick chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.

Actually, should you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, should you actually take into consideration all of the issues which can be being carried out within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it truly impacts the entire physique together with our mind to coming again to it, Katie, that you just identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, you already know, you’ll be able to name them any names you need, you already know, a lot of these items together with autism is now linked straight into the intestine microbiome. Actually, they’ve carried out now the analysis the place they did merely a microbial transplant known as a fecal transplant they usually have been capable of the truth is present that youngsters with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been capable of present once you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. And so they’ve carried out them in mice they usually’ve carried out that the truth is in people, and clearly, it was carried out by mistake however that’s truly the way it occurred.

Actually, what’s actually fascinating is habit. And so they’ve proven the identical factor. They took…there have been 17 individuals on the analysis that have been utterly hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who truly had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the habit is, proper. And I believe that’s actually phenomenal.

And now what we’re studying is each sort of most cancers…the truth is what they’ve now checked out is each single stable tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there may be microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism desirous to survive would ever show a microbial peptide until it’s there to idiot our immune system into considering that is self and protects the tumor towards the immune system attacking, proper?

Now, think about what…one other factor that’s most fascinating I discovered was once you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the those who immunotherapy didn’t work, they merely have been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome is just not solely there to maintain us wholesome from all of the illnesses in the present day we name the completely different names. Coronary heart illnesses, it’s coming from our intestine microbes truly producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. Actually, we will now take a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites truly change the LDL manufacturing. You’re ready to have a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.

And so, anyway, the purpose I’m making an attempt to make is that you just talked about one thing about these micro organism, and I simply need individuals to know the microorganisms should not simply micro organism. They’re predominantly micro organism however additionally they include yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the most important half the truth is should you seen virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And should you take a look at any nature whether or not you’re wanting within the swamp otherwise you’re wanting on the intestine microbiome, the truth is there are 10 occasions extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that the truth is adjustments how these micro organism behave when it comes to what features they’re performing.

So once more, what’s actually fascinating is by taking a look at what organisms are there, won’t ever inform you what’s going on in your physique. Actually, their features are what makes the distinction. Meaning what they’re producing can…is basically the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you in all probability know that lots of the individuals like Akkermansia muciniphila. Among the corporations are promoting them as a probiotic with out realizing that Akkermansia may be good for some individuals and in reality it’s the primary cause for inflicting a number of sclerosis, and it has additionally been straight linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and may do one thing actually dangerous in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally completely different than different individual’s physique. The identical organism or identical probiotic may be good for somebody and could possibly be dangerous for one more individual. And that’s the most important studying we’ve had within the final six years.

Katie: Yeah, I really like that you just introduced up the fecal microbiota switch as properly. I’ve seen a number of the science on this and… you already know, caveat, this isn’t one thing to try at residence however it’s fairly superb what they’re engaging in in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you’ll be able to accomplish with out having to go to that excessive if you already know what you’re working with. And for the final two years, I’ve been saying, you already know, early on in well being and wellness, I might discover out data, learn research and be so excited and write about it, and I’ve realized increasingly more during the last 15 years every thing is so personalised and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “, I can inform you what I did however it’s not gonna work the identical for you. It may be an thought with the start line however it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very completely different.”

Which is why I really like now increasingly more entry to those at-home testing whether or not it’s issues like Viome, even now blood testing obtainable at residence, genetic testing simply so we will have extra data and entry. And I’ve mentioned so many occasions on right here we’re every our personal main healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal main healthcare supplier. And I really feel like having instruments in our pocket that permit us be more practical at that may actually, actually make a distinction. So, let’s discuss somewhat bit extra concerning the personalization side of this as a result of I additionally am curious…you already know, I do know you mentioned every thing is so completely different. What’s good for one individual could be not for one more. Are there any issues which can be sort of universally dangerous that you just’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross record, however I’m curious what you’re seeing within the knowledge.

Naveen: Yeah. So initially, it’s actually fascinating. I believe you phrased it appropriately. There isn’t any such factor as common wholesome meals. And which means there isn’t any such factor that’s good for everybody. Meaning the identical meals may be good for you or dangerous for somebody. Nonetheless, there are some common unhealthy issues which you could know. So, there isn’t any common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t any one who says, “The sugar is nice for me, proper.” In order that’s truly having a fried, you already know, fried meals. So, all fried stuff, it’s simply dangerous for everybody. Consuming lots of sugar, it’s simply dangerous for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing primarily based on what’s going on and what’s dynamically altering in your physique…and I believe lots of the people who find themselves listening to it, I would like individuals to grasp the distinction between a DNA which is static. So when individuals do their DNA check, it tells you what’s inherently there in your physique. It doesn’t inform you what is definitely happening in your physique. Meaning…if, Katie, you permit me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.

So, each a part of our physique is an identical DNA. Meaning you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are beneath expressed, the identical DNA can turn out to be eye, identical DNA can turn out to be nail, identical DNA can turn out to be pores and skin, identical DNA can turn out to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each doable factor that may occur. And that’s one factor.

So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and inform you…some information to share with you in the direction of the tip. As soon as we perceive all that’s happening, we’re capable of then inform you, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is just too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so you must reduce it down, proper.”

We are able to inform you that…lots of people will inform you go take vitamin B3. However vitamin B3’s truly not good for you when you will have excessive uric acid manufacturing. So don’t take vitamin B3 when you’ve got excessive uric acid manufacturing. Equally, everybody will inform you, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t wish to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people suppose in some way taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some individuals it might do this, however for others it truly will hurt you when you will have excessive mobile senescence, or when you will have excessive inflammatory exercise. You don’t wish to be taking further NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.

So, the concept actually is that you must study what is going on earlier than you deal with your physique like a black field. And I believe you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is going on in our physique as a result of our main care physician…I don’t find out about you, Katie. Once I go to my main care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the sick, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t must…they don’t care to grasp what’s inflicting that to occur in my physique. Like, you had Hashimoto, or should you had any sort of an autoimmune illness, the very first thing they inform you is simply take the immune suppression medicine and suppress the symptom. Not fear about what’s inflicting it, and that may be a elementary drawback that our healthcare system has is that our medical industrial complicated, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to vary that. In my world of the long run, Katie, we imagine that…I believe similar to you simply mentioned, the way forward for healthcare goes to be delivered at residence, not on the hospitals.

And the medicines of the long run are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I might say should you look again at COVID 10 years from now, it will likely be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.

Katie: Completely. I believe so many good silver linings and instructing moments in COVID and folks spent extra time at residence and with their households cooking dinner at residence. There have been lots of nice outcomes, as onerous because it was for many individuals. I believe we will give attention to these positives. And I really like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go somewhat bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some large advances since then. So, discuss sort of the snapshot of what Viome is testing after which how persons are making adjustments primarily based on that and what they’re seeing.

Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good however it didn’t inform us how these intestine adjustments have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID truly, we launched our well being intelligence check that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now take a look at each your intestine well being and your human host and capable of now inform you what’s your organic age. And that tells you not solely, you already know, how properly or how poorly your physique is getting older in comparison with your chronological age.

So, to provide you an thought, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the stage after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than the truth is I had after I was 50. And that merely tells you what your organic age is. Then we offer you immune well being. Meaning how properly are you protected towards should you have been to catch flu or chilly or any sort of pathogen, how properly your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you the way properly your cells are capable of bear the issues which can be happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing facility. How properly the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We offer you clearly your intestine well being.

And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from high of your tube, your saliva, your stool and blood, all three on the identical time. And by taking a look at that, we’re additionally gonna be capable of present you some further insights equivalent to your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna be capable of present you your oral well being equivalent to your gum well being, your tooth well being and all of the gum, you already know…leaky gum as a substitute of simply leaky intestine. We’ll be capable of present you the way properly your boundaries of your gums are performing in order that microbes should not going into your blood.

And different factor we do now which we didn’t do till a couple of yr in the past is once you do a check, not solely you get your deep perception what’s occurring in your physique and never simply inform you listed below are the meals which can be good for you and right here is why. Listed below are the meals you must keep away from and why. We used to inform you listed below are the dietary supplements you must take. Now we transcend that, Katie. We’re capable of inform you you solely want 22 milligram of berberine day-after-day. You want 17 milligram of elderberry day-after-day. You want 79 milligram amylase day-after-day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.

There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we modify your dietary supplements on the identical time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of alter your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.

Different issues that I’m actually, actually enthusiastic about…and we’ve not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll be capable of spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable of inform you when you’ve got any oral most cancers or throat most cancers. After which we’ll be capable of truly join you with a health care provider to have the ability to do one thing about it. So, in case you are above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable of truly at residence do a check and truly know that you just’re not at a danger of creating a most cancers proper now. Otherwise you’re creating a most cancers proper now.

Katie: Yeah. That is so leading edge and I believe simply to focus on what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive expertise. And since you’ve now examined 1000’s and 1000’s, in all probability a whole bunch of 1000’s of individuals, then the algorithm has entry to all this data so it might probably proceed to get increasingly more specialised and direct with the suggestions and study your personal physique over time. So, you’re getting this sort of ongoing, correct image which I believe is so fascinating.

Naveen: Yeah. So, Katie, we’ve analyzed over 350,000 samples already. And that has given us this…you already know, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that we’ve analyzed they usually contribute to the ecosystem, and our AI and machine studying is consistently getting higher. And for each single one who joins profit themselves and advantages the humanity on the identical time as a result of now the extra we study, the higher suggestions we will make for everybody. So, earlier than we simply solely might take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the following factor will likely be with urine. After which we’re gonna begin to have a look at different biomarkers in your physique. So, our suggestions get increasingly more exact as we study increasingly more concerning the human physique. And our actual hope is, you already know, in my lifetime we’ll be capable of perceive what causes the onset of a persistent illness and what causes them to progress and to have the ability to stop them from occurring within the first place, to diagnose them early once they truly do occur, and to give you a remedy for these illnesses. Not merely handle them however to remedy them as soon as for all for every particular person. And that’s going to be the last word purpose of our life.

Katie: And I really like that you just introduced up the interplay of all of the completely different microbiomes inside the physique as properly and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying for example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the identical time. And it’s because we’ve an oral microbiome. And if it will get out of steadiness in a single route or the opposite, you’re gonna find yourself with these issues. However the reply is just not sterilizing your mouth and killing all micro organism similar to we wouldn’t wish to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you mentioned, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally doing a little fascinating analysis with the vaginal microbiome and I’m excited to speak along with her about that.

However I believe, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra sort of intricate knowledge we will get to make enhancements over time and naturally there can be a most cancers connection right here. , I’ve heard it mentioned that most cancers is a metabolic illness in some half. And it is a method of…as a result of even inside a person, should you’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in examine. We have to get blood strain in examine. We have to get weight problems measures in examine.” However the best way to do this’s gonna be completely different for each single individual.

Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s induced…persistent irritation is a root explanation for persistent illnesses. Nonetheless, what causes the irritation in our physique is completely different for every particular person. So though it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very completely different. And as you talked about, our daughter is, you already know…has this firm known as Evvy, E-V-V-Y, which appears to be like on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single lady ought to do this as a result of that’s actually…goes to be…you already know, plenty of ladies endure by way of most of the illnesses that we as males would by no means perceive. And that to some extent is, you already know, largely reproductive organ and most of the occasions the later analysis reveals that vaginal microbiome is concerned in preterm start, within the well being of the infant and all of the issues that you just talked about because the child goes by way of the start canal. All of the issues that come out the truth is are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I believe each lady needs to be doing the Evvy check, proper.

Now, coming again to the belongings you talked about that, you already know, human well being is complicated however as soon as we perceive biochemical stage what’s going on, that’s the rationale as a substitute of taking a look at organisms and as a substitute of taking a look at DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Trying on the complete physique. And I believe, Katie, I wanna level out that the merchandise that you just construct for oral well being are a number of the finest merchandise as a result of, to me, what’s the largest gamechanger is individuals thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. While you kill the ecosystem in your mouth, it truly destroys the entire digestive tract. And I wanna simply emphasize, you already know, to individuals when our moms advised us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too large to go down our esophagus, proper. It was truly was once you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.

So, the primary factor is that we have to permit the oral microbiome to predigest the feed so your small gut can now take up the vitamins which can be already predigested. So, when you find yourself…so two issues it is advisable take into consideration right here. And one is when you find yourself harassed and you’re consuming your meals, it doesn’t get correctly digested and right here is why. When you find yourself harassed, you’re in a combat or flight response. And the primary factor that occurs once you’re in combat or flight response is your digestive system shuts down. Keep in mind why it was designed. While you’re operating away from a tiger, at the moment, the physique knew there isn’t any level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And should you grew to become lunch for another person, it didn’t matter. And should you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you possibly can digest your meals.

While you come from work and you’re harassed, what can we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you wish to carry your physique from sympathetic mode into parasympathetic mode. Eliminate combat or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy methods we realized within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you could not know that my mother and pop and our faith, they don’t eat after sundown. And I all the time marvel why would that be. And it seems as a result of it is advisable have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, the truth is telling that, you already know…and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.

And I wanna come again to the oral merchandise. I believe individuals should be actually fascinated about oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you already know, probiotics. And the merchandise, a number of the merchandise that you’ve got, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to begin concentrate as a result of that’s the primary. Your mouth truly is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.

Katie: I completely agree. I believe very multifaceted however begin with the mouth is so essential. And I really like a few the belongings you simply talked about about why we don’t digest meals if we’re harassed and we all know, after all, that Individuals dwell in a persistent state of stress usually. And one factor I’ve turn out to be keen on…you already know, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you’ll be able to merely do respiration workouts. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a non secular perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice after I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I seen after I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you may be therapeutic and your physique can get into autophagy and you’ll allocate assets to all of the pure processes the physique has inbuilt to maintain us wholesome.

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And I additionally wanna piggyback on what you mentioned about the identical cause we don’t wanna kill our oral microbiome is identical cause we don’t wanna kill our intestine micro organism as properly however I nonetheless see individuals sort of hopping on the bandwagon of those actually harsh cleanses or after all individuals typically take antibiotics for causes whether or not they should or not. And people can each have a fairly harsh impression on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine situation associated to actually sort of killing a few of these good micro organism. Clearly, Viome helps with this however sort of, like, what may be carried out? How can we assist repair it?

Naveen: So, very first thing is, you already know, earlier than you go begin taking lots of issues is to grasp, what’s the state of your intestine micro organism? So do a Viome check, perceive the place it stands. And then you definitely begin to have a look at what you…you already know, we inform you what are the meals you must eat. And once more, taking lots of the fermented meals particularly once you’re making an attempt to repopulate or rebootilate your intestine microbiome, actually the issues needs to be diversification. So as a substitute of simply taking one sort of probiotics, you ought to be taking kombucha, the kimchi, the…you already know, all of the fermented meals you’ll be able to presumably get your palms on. So, whether or not it’s a yogurt or, you already know, no less than oat milk yogurt should you can. I imply, I’m a giant fan that I believe dairy…the truth is for lots of the individuals, dairy is the large drawback. Now I’m not saying it’s for everybody however lots of the individuals, dairy could possibly be a giant drawback. And the mammalian merchandise truly could possibly be a giant drawback for some individuals and never for others.

So, I’m not the one who is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat pink meat for all of their life and dwell to be 100, and the rationale for that’s pink meat comprises clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the guts illness. So, it’s not the pink meat that causes the guts illness. It’s the byproduct of how the pink meat is digested in some those who produce TMA. So, in case your TMA manufacturing is low, you must eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to grasp, don’t merely ban meals and complete class of meals.

One other factor that we realized…we revealed a paper having analyzed over 100,000 individuals at the moment on getting older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you already know, keto food plan or paleo food plan have been the worst offender of their organic age. The individuals who have been on keto food plan the truth is have been three to 5 years older than their chronological age and the identical is true for paleo food plan. It seems that people who find themselves on balanced food plan, which means they have been consuming their carbs however not loads however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats they usually have been consuming the protein, they have been far more balanced, have been truly higher off biologically than slicing out the entire nutrient group utterly.

Katie: That is smart, that we want the range. And I’ve realized increasingly more as properly that I believe the simplistic model all of us realized, hopefully realized at school was about simply sort of energy in, energy out. And I’ve heard it mentioned, you already know, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra various and essential than that.

And what’s subsequent for Viome? I’m curious as a result of I do know you’re always doing analysis right here, and such as you mentioned, your purpose is to deal with persistent illness in its entirety. So, what’s within the pipeline for you guys?

Naveen: Truly, I discussed that subsequent check we’re launching in June is a full physique intelligence. We’re launching a most cancers detect check. And we’re making our dietary supplements and probiotics increasingly more exact for each particular person since we make it for every particular person. We’re, you already know, making an attempt to do further assessments now and our purpose is to launch within the subsequent six months one other check which is gonna be extra, like, a proteomics check as a result of the issues we can not see within the blood as a result of they’re produced some place else. So, can we measure issues, you already know, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict when you’ve got a leaky intestine by taking a look at LBP, by taking a look at CRP which truly is finished within the liver? So, we’re going to have the ability to truly measure further issues along with simply those that we’re measuring, and the extra data we will study, the higher suggestions we make. So, our hope is to proceed to launch these assessments that give us higher and higher insights and which means we will make increasingly more exact advice for every particular person.

Final purpose actually is to grasp…as you say, the human physique is a chemistry lab. We’ve mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to grasp that the gene expression tells you what biochemistry is occurring within the physique. And that’s a cause…and in reality, Viome is the one firm that does take a look at the gene expression as a result of there isn’t any different firm that has this expertise. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense mission. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of assets to develop this expertise. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to earn a living, we might not have been capable of license this expertise, proper.

So, the actual fact in the present day we’re merely targeted on making each single individual be higher. , our mission on day one was what if we might perceive the human biology at a molecular stage so we will stop, diagnose early and remedy these persistent illnesses together with most cancers and getting older? And I believe lots of the individuals who have heard you and I discuss previously, you already know that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I might have probably saved my dad. And, you already know, having watched him undergo that ache or struggling by way of most cancers I noticed that though I couldn’t save him, I might dedicate my life to saving everybody else. And that will likely be my method of letting him know that, you already know, I’m so pleased with what he…how he raised us as a baby and giving us every thing we’ve so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.

And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I have been to make a prediction in the present day, I’ll inform you inside a decade I believe we are going to eliminate most cancers from the human physique.

Katie: That’s a giant declare and I hope we’re on monitor for that as properly. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the persistent stress of the final couple of years is just not serving to that drawback. So, I’m grateful that there are assets such as you, and I’ve carried out Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be sure…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. You could find the low cost code and the hyperlink on to it there. And to ensure I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a guide or various books which have profoundly influenced your life. And in that case, what they’re and why?

Naveen: Yeah, so the guide that basically influenced me…there’s a guide by Clayton Christensen, you already know. I really like the person and I noticed him earlier than he died. The guide he wrote, “How Will You Measure Your Life?” And to me it was such a profound guide which tells you that you must be 100% trustworthy. You can’t be 99% trustworthy as a result of as soon as you’re taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be one more reason to make an exception. And so, you must focus your self to by no means, ever compromise in your rules that you just stand for. And that was simply completely a fabulous guide I learn.

, the guide that additionally…I imply, clearly I wrote a guide known as “Moonshots” that’s actually about making a mindset of abundance relatively than a mindset of shortage. And the basic perception that I’ve is that there’s nothing that people should not able to doing if we truly get our mindset to imagine we will. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to resolve whether or not they can or they will’t. That after you imagine one thing is not possible, it turns into not possible for you and nobody else. And so, you’re utterly in management. The one factor you’ll be able to’t do is what you’ll be able to’t think about. Every part else is feasible.

Katie: I really like that. I do know you and I each elevate our youngsters with that mindset and yours are older and doing superb issues out on this planet already and mine are to start with levels of that. And lastly, what parting recommendation would you want to depart with the viewers in the present day? Could possibly be associated to one thing we’ve talked about or solely unrelated.

Naveen: I might say dream so large that folks suppose you’re loopy. Meaning by no means let somebody inform you which you could’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self is just not about being self-conceited. Loving your self is about not on the lookout for another person’s approval to do the issues that imply loads to you. Observe your coronary heart, observe your intestine, take heed to your intestine and observe what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever suppose it’s work. I stand up day-after-day at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, should you’re not leaping out of the mattress, you must stop what you’re doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to resolve that drawback.

And, Katie, I simply wish to reiterate, I met your youngsters and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your youngsters are going to truly transfer this humanity ahead. You’re elevating these kids with the mindset that every thing they wish to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it lots of occasions. Like, after we elevate our kids, we inform them, “Our love for you is unconditional however our approval is just not.” And what which means is just is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna inform you I’m pleased with you until you do issues that make us pleased with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It will likely be measured by what number of lives they enhance. And the humility is an indication of success as a result of should you nonetheless have iota of conceitedness left in you, which means you’re nonetheless making an attempt to show one thing to your self or another person. And humility tells you not have to do this, proper. And that may be a true signal of success. And all I can say is I’m so pleased with each one in all your kids, Katie. And I can not await them to develop up and truly do issues that may make our kids’s and grandchildren’s life higher.

Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over truly parenting earlier than we ever talked about well being. And we share that similarity. I inform my youngsters day-after-day, “I really like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you possibly can ever do that might take away from my love.” However you’re proper. Additionally, I would like that, like, their satisfaction to come back from within, like…and I inform them usually, “You will need to really feel actually pleased with how onerous you labored and you should…” As a result of I would like them to have that inside them and that self-love.

And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening in the present day of mothers, as a result of I believe mothers have such an incredible distinctive means to actually shift the way forward for humanity by how we father or mother our youngsters and by serving to type these future leaders. And for individuals who aren’t already accustomed to you, I might encourage you to take heed to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your youngsters on their life journeys and your spouse in her personal proper is unimaginable as properly. So very grateful to your complete household and for all that each one of you’re doing on this planet and to your time in the present day. I understand how busy you’re and I’m so grateful you took the time to be right here.

Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m wanting ahead to our subsequent dialog.

Katie: And thanks, as all the time, to all of you for listening and sharing your most respected assets, your time, your vitality, and your consideration with us in the present day. We’re each so grateful that you just did. And I hope that you’ll be a part of me once more on the following episode of the “Wellness Mama” podcast.

 

When you’re having fun with these interviews, would you please take two minutes to depart a ranking or assessment on iTunes for me? Doing this helps extra individuals to seek out the podcast, which suggests much more mothers and households may benefit from the knowledge. I actually respect your time, and thanks as all the time for listening.



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